A UCLA-led study found that a low dose of a commonly prescribed dose of aspirin delivered in a single session led to a significant reversal of congestive heart failure, improving quality of life among 54 percent of study participants. The research was published in JAMA Network Open.
Certain medications and certain lifestyle changes can enhance the effect of aspirin in treating congestive heart failure. To reach these conclusions, the team conducted a trial with 954 participants determined to test the effect of a low dose aspirin treatment delivered on a single time point (1500 mg/d) among 54 patients. Their blood pressure was measured continuously during 18 months of the trial.
The researchers found a significant decline in the time to the first episode of chest pain (time to 2-4 weeks after starting aspirin treatment) with a low-dose aspirin treatment. In contrast, the proportion of participants who reported no adverse effects significantly increased.
Another incidental finding was that healthy people who had no chest pain and did not have congestive heart failure were more likely to stop or reduce doses.
In addition, those who went through a major swelling during the clinical observation period with low-dose aspirin showed no significant improvement.” The dose-escalation trial of aspirin appears to have had little impact on [clinically significant] [congested] disease[, nor the impact of] [other] factors,” the researchers wrote, adding that the avoidance of potential placebo-challenge factors for aspirin or placebo was not statistically significant.