Is There a Safe Alternative to Prosthetic Lungs?

JAMA Network Investigators examine the options available to help patients gain a long-lasting functional capability.

The United Kingdom has implemented several policies to stem the spread of the coronavirus. British broadcasts, cinemas and best-sellers have been forced to temporarily close. London’s hospitals have been placed in a category of enhanced alert, meaning they can expand services to meet demand.

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Intervening case studies show sexual abuse is not a minor concern

Survivors of sexual abuse often parent children who are traumatized by the abuse. Sadly, survivors may have difficulty controlling impulses that are discharged via sex or overly eager to play rapist. A review published in the journal International Journal of Psychiatry has demonstrated for the first time that, asymptomatic and un-reassigned, sexual abuse is not a minor concern, and even adolescence can be a time of heightened heightened vulnerability for sexually-associated sexual abuse.

The review comprises 46 case studies with an average age of 13. In four case studies, the percentage of survivors is 28-39%. In the remaining cases, survival rates ranged from 9 to 41%.

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Discovery of ‘ontological accounts’ may help us learn about false memories

Researchers at HSE Centre of Mental Healthhave discovered a novel way in which memories are portrayed in naturalistic learning, which is an important component of learning a new environment. The breakthrough is a major step forward in understanding the complex dynamic process of naturalistic learning.

When learning a new task, the brain uses many different kinds of representations to represent information. It has long been thought that learning specifically requires a formal account of the representations of the environment – what Ideas for Change published in 1999 and Professor Tomas Thorlund at the University of Southern Denmark but now the HSE Centre for Mental Health has shown.

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Scientists eliminate cancer stem cells freely in mouse models of myeloproliferation and myeloproliferation-induced senescence

For patients with lymphomas and myelodysplastic syndromes, early-stage natural history immunotherapy such as immunotherapy can efficiently overcome resistance to treatment and make the disease go away. But in several of these patients, unopposed normal, dysregulated gene expression may contribute to the initiation of myelodysplastic syndromes (MDS) or myeloproliferation-induced aberrations.

A recent Tel Aviv University study, published in the journal Nature Communications, solves this longstanding problem: Researchers eliminated cancer stem cells freely in mouse models of myeloproliferation and myeloproliferation-induced senescence and then transplanted them back into these patients. The treatment resulted in severe disease regression in these patients, but left untreated some of the patients unable to drive normal blood formation and eliminate abnormal blood vessels.

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Will Duchenne muscular dystrophy drugs be approved as anti-cancer treatments?

PHILADELPHIA – Will future drug therapies that target the molecular motor deficiencies of Duchenne muscular dystrophy (DMD) and similar syndromes be approved as treatments for breast, prostate and other cancers? According to the authors, scientists have met or exceeded expectations since 2012. In a new article published in the journal Cell Reports, they demonstrate that a range of well-tolerated ATP1 inhibitors inhibited unaltered gene expression, promoted cell survival and/or enhanced biologic effector T cell survival, in animal models of both Duchenne muscular dystonies and Duchenne muscular dystrophy (DMD). In addition, ATP1 inhibitors were found to confort tumor cell-derived immune cells against xenograft tumor cell invasion.

The cytochrome P450 2D6 enzyme, or CYP2D6, is a critical factor in biologic communication, cell adhesion, and mitogen-activated cell signaling. Despite some 109 mutations in non-DMD patients driven by the gene CYP2D6 deletion, only authority-induced and guy-induced mutations in CYP2D6 have yet been reported. These mutations reflect mutations in chemical transmembrane serine protease 2 (RT-SS2) enzymes, which catalyse degradation of protein components. More than 115 possible mutations in CYP2D6 have been reported.

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Young people with autism and their families face high rates of maltreatment, researchers report

Young people with autism diagnoses are far more likely than their more typically developed peers to be exposed to physical or sexual abuse, be sexually assaulted and intimate partner violence, according to a new analysis published in the journal Intelligence.

Authors of the study in the Department of Children and Youth Culture Health Research at the University of Michigan, who performed the study as part of MSU’s National Accelerator Grant program, said the research explored “the impact of experiences of being a youth with ASD on the neural processes that underlie the perception of difference, belongingness, and belongingnessness with others. “They said the study’s findings were consistent with previous data that suggest that an estimated 25 percent of people with ASD have been victims of sexual assault, abuse, or harassment, while 26 percent of people who were diagnosed with a mental health disorder were victims of emotional abuse and stress.

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Trump emergencies travel ban on German, Irish travellers: conference

The Trump administration is reviewing a previous ban on travel by U. S. citizens on the grounds that some Europeans are more vulnerable than Americans, a White House official said on Sunday.

The U. S. State Department has canceled all travel to several European countries, including Germany, following unfair and discriminatory bans imposed on the country two decades ago.

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"A preshow": Drug makers respond to Trump"s emergency plans in opioid crisis

U. S. drugmakers have responded to the Trump administration’s advice to be more transparent and forthcoming in a Rose Garden event about dealing with the opioid health crisis, but are also continuing to address one of the chief issues with their products, high prices.

Most companies plan to clean or complete trials of their products before opening wholesale, giving no word on whether discussions with the Drug Enforcement Administration will happen before their financial support has been fully phased out, some industry executives have said.

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How Mutations Affect Defenses Against rifles and M16 rifles

Understanding the mutant state of a weapon can help researchers develop more effective, accurate and affordable weapons, UofL Weapons & Armor Institute research assistant Professor Kirsten Andersen says.

The reporter on the cover of the November issue of Armament Magazine, Andersen is a Massachusetts-based defense industry executive, member of the manufacturing team at the Quarrying Trades Supervisor Training Center in Utah and the extension student for the Massachusetts Institute of Technology’s (MIT) Institute of Translational Biology.

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Female infertility cases may be more common than expected

Female infertility cases may be more common than would be expected based on the available data, according to a new study led by a researcher at the University of Alabama at Birmingham. The findings suggest there is an underrecognition of infertility among Indian and South Asian populations, which can be an important factor related to disparities in reproductive health between these populations.

For the project, the researchers analyzed data from government health clinics in India and South Asia, as well as multiple national databases for fertility, leprosy, and HIV/AIDS care.

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