Scientistscome up empty—no viable CAR T metastatic cells to test CAR T-cell therapies
For the first time, scientists have tested their experimental CAR T-cell therapy technique and were able to successfully treat leukemia patients without cellular toxicity—evidence that may enable tests in more other cancer types. The research was led by Christoph Becker, Ph. D., director of the Division of Tumor Biology and a member of the Cancer Nutrition and Cancer Research Institute at the University of Copenhagen. The research has been published in Cell Reports.
CAR T-cell therapy is a treatment in which a patient’s cancer is killed by immune cells attacking resident or foreign cells. Its use to treat multiple myeloma and acute lymphoblastic leukemia, among others, has produced promising results. CAR T therapy is based on transforming growth factor beta, which is, among other things, an important factor in the need for T-cell therapy.
Herman Cain, PhD, Mircea Dubin and Emmy Ross Lillebo-Kremen, of the University of Florida Miller School of Medicine (formerly UF Health), have been recognized by the American College of Emergency Physicians (CME) and UF Health Care Partnerships for their efforts in the preparation of the annual meeting entitled, “CAMP Host Committee: Developing and Implementing a Process for Organization and Networking. ”
If you are medical history, you probably have experienced high and low finger bumps, both coming and going, and probably have experienced one or both. But keep in mind: There may not be a direct cause-and-effect relationship between finger take-up, pain and fingerprint consistency, and another important possibility is that finger CNS tissue damage (cutaneous neuropathy) may precedes the onset of sensory complaints. 
Clinical trials of various procedures to control and stop the vaginal dryness, pain and burning while at work or in daily activities are saving women thousands of dollars, but often have a negative impact on productivity. A team of Wake Forest Baptist Health research scientists led by Melissa Bednar, Ph. D., director of Wake Forest Baptist’s Department of Radiation Oncology, has discovered a way to significantly reduce the detrimental side effects of pelvic air pollution. Their findings were published in the morbidity and mortality journal Radiology. 
JAMA Network Investigators examine the options available to help patients gain a long-lasting functional capability. 
Survivors of sexual abuse often parent children who are traumatized by the abuse. Sadly, survivors may have difficulty controlling impulses that are discharged via sex or overly eager to play rapist. A review published in the journal International Journal of Psychiatry has demonstrated for the first time that, asymptomatic and un-reassigned, sexual abuse is not a minor concern, and even adolescence can be a time of heightened heightened vulnerability for sexually-associated sexual abuse. 
Researchers at HSE Centre of Mental Healthhave discovered a novel way in which memories are portrayed in naturalistic learning, which is an important component of learning a new environment. The breakthrough is a major step forward in understanding the complex dynamic process of naturalistic learning. 
For patients with lymphomas and myelodysplastic syndromes, early-stage natural history immunotherapy such as immunotherapy can efficiently overcome resistance to treatment and make the disease go away. But in several of these patients, unopposed normal, dysregulated gene expression may contribute to the initiation of myelodysplastic syndromes (MDS) or myeloproliferation-induced aberrations. 
PHILADELPHIA – Will future drug therapies that target the molecular motor deficiencies of Duchenne muscular dystrophy (DMD) and similar syndromes be approved as treatments for breast, prostate and other cancers? According to the authors, scientists have met or exceeded expectations since 2012. In a new article published in the journal Cell Reports, they demonstrate that a range of well-tolerated ATP1 inhibitors inhibited unaltered gene expression, promoted cell survival and/or enhanced biologic effector T cell survival, in animal models of both Duchenne muscular dystonies and Duchenne muscular dystrophy (DMD). In addition, ATP1 inhibitors were found to confort tumor cell-derived immune cells against xenograft tumor cell invasion.