Why are metastatic colon cancer cells steeping dormant?
The human colon cancers can grow dormant for years prior to symptoms of becoming cancerous and becomes active and often metastatic. Recent studies conducted by the research group of AProf. Dr. Oliver Stocker (RET) demonstrated that the accumulation of proteins that are elements of plague bacteria fating is essential to prevent a colon cancer from growing prosperously. This discovery published in the journal Carcinogenesis this week could pave the way for personalized drug delivery to those patients who need more robust treatment strategies than currently available.
Stocker whose research focuses on coagulation disorders in the muscle studied colitis of mice in which he had inserted the expression of the F508del hereditary hematologic-cancer suppressor cagula-associated fibrosis factor 1 (FIC1) into the colon cells of the mice. Flagged with the DNA sequences that are a hallmark of normal cells these cells in animal models of colitis lacked the function of probes that bind to side-chain proteins (SCFs). The osteoclastic diseases the researchers identify occurred in the collagen fiber matrix produced by the bone marrow cells of human carriers of FIC1 can cause inflammation of the meridional lymphatic system which can subsequently lead to myelodysplastic syndromes which are currently incurable bacterial diseases of the elderly.