The link between cancer and blood vessels

Scientists at Kyoto Universitys School of Experimental Radiation Biology and Medicine (SR-RMed) found a new link between radiation of different kinds (perturbations in plasma blood vessels bone and nerve tissue) and various types of cancer (leukemia brain pancreatic and others).

By using an epigenetic modification technique the scientists have identified the importance of such modifications in the function of blood vessels in normal physiological situation and the way in which they are involved in promoting pathological processes.

Murine circulatory processes have been modified by radiation chemotherapy via the use of a combination of subcutaneous light and DNA thermal cyclers but the study of the cellular mechanisms involved points to the epigenetic modification of these processes to regulate blood vessel function has been incomplete. The scientists hope to determine whether such modification is directly involved in the secretion of radioactive elements directly from cancer cells or via modification of circulating molecules derived from cancer cells and cells being destroyed by reactive oxygen radicals.

We were interested to understand the mechanisms underlying the regulation of circulatory systems in various types of cancer and to determine whether the effects of radiation in circulatory processes are dependent on cell survival through the activation of circulatory processes explains Miyulit Kanaji post-doctoral researcher in the Ukiyama Graduate School of Medicine Graduate University Science Technology Center Kyoto University and University of Tokyo totranslated by ARU researcher Kazuyuki Wada. He was chief scientist at the prefectural and hospital level of the Osaka Prefectural Cancer Association.

The researchers altered circulatory processes by irradiating various types of cells measured the reactive oxygen and assessed the effectiveness of the treatment in different time points in mice. GTE (general lethal cell effector secretion) cell death induced by irradiation caused a reorganization of physiological circulatory system functions so that circulatory functions and blood pressure were affected. The effects of radiation on circulatory network function were analyzed in detail by fundamental mechanics researchers from the Kumamoto University Graduate School of Engineering and the University of Kyoto.

Chronic exposure to various types of radiation induced circulatory modulations with prolonged irradiation even at 1 Amu (upper limit recommended limit of a typical day of human exposure) and prolonged exposure to gamma radiation induced circulatory depression induced cardiac hypertrophy and changes in peripheral blood pressure.