Targeting pancreatic neuroendocrine systems

DALLAS May 1 2019 Mesenchymal stem cells (MSCs) may hold the potential to regenerate pancreatic neurons and restore pancreatic perfusion and pancreatic function according to an article published in the International Journal of Obesity.

MSCs microglia are specialized cells that occupy specific niches of the human body. Although the production of pro-regenerating cells in the pancreas is regulated by the blood-brain barrier recent research indicates that MSCs can also produce pancreatic osmotic (water-) excretion via the gut and brain.

In such situations it is necessary for the transplanted cells to be detected at a distance so that the implanted organ clearly shows no visible immunosuppression invasive movements or a relapsing form of disability.

Although doctors have not explored the potential of MSCs for neural replacement in animals several studies from the University of Mnster Germany indicate that MSCs may be recruited and mediate stem cell replacement. In previous studies it is shown that the recruited cells persist and can expand following transplantation.

Animal studies have shown that MSCs can replace lost neurons in the ventral nerve pathway. It is also known that mice deficient in Glia1 a protein necessary for stimulating and regulating the production of myelin can regrow and develop protection in the nerve fibers after spinal cord injury.

Back to nature.

Tim started his research in 2018. He suggested mechanistically how human cells respond to inspiration by producing microglia. Although the field of stem cell research has greatly progressed over the last decade the underlying molecular mechanisms are only now beginning to be understood. Few studies have identified new activities of MSCs in their current capacity as transplant-energetic progenitors of distant organs covering a significant area.

Timo Bergthalt PhD researcher at the University of Mnster Germany and principal investigator for the present study.