Study Miles Comprise of Variations in Eyes and Gums
A new study by Philip Bondy Ph. D. was recently published in the Journal of Neuroscience the Official Journal of the Society of Neuroscience (SNS). The paper which was authored by Buck professor of neurology Vadim Nikonov Ph. D. of the University of California San Francisco (UCSF) and Boris Gheszov Ph. D. of the University of Haifa provides an overview of the findings regarding the relevance of the Prader-Willi condition which causes visual disturbance and presents varying outcomes.
The search for primary abnormalities of the central nervous system identified 6 of the more than 50 prader-willi patients. The abnormal findings were presented at the annual meeting of the International Neuropsychopharmacological Society held in Batavia Lithuania in January 2020. This unique neurological disorder causes individuals to exhibit abnormal visual movements specifically when performing a task involving touch. This can be detected between childhood and late adolescence. As such the deficiency can develop into a permanent disability. One of the most frequent reactions of the patients is a loss of the sense of taste. Over time the deficits in taste become so severe that individuals are unable to detect food taste or avoid unpleasant odor while others are able to detect mild smells such as smoke.
In the retrospective study researchers reported that the vision of some of the patients is impaired. Since there was a marked reduction in their visual acuity the observation was made that other patients reported short-sightedness. Brain MRI images of 13 out of the patients revealed significant involvement of the retina in visual processes but did not reveal any other visible brain damage. In comparison their report showed a significant deficit in the orbito-occipital complex an important part of the frontal cortex in the central nervous system.
Patients were asked to perform a series of tests on themselves. They remembered which letters they had seen in certain contexts during the previous two days with between 60 and 90 percent accuracy. Sensorsearphones were implanted into the ear to measure responses to odorant stimuli and to determine the visual form of the words coming out of the ear. These tests were repeated over a period of almost 10 months. The scientists expect to reproduce these findings in a much larger sample and with even more accurate tests to validate the results.
The authors conclude that the observation diversity in the patients suggests that primary anomalies in the central nervous system investigate the visual and behavioral deficits related to this. In particular the authors suggest that visual acuity abates at age 20 with these atrocious findings and at the same time onset is noted in many individuals with DIPG. There are indications that these findings constitute a dysmorphological anomaly in this neuropathology.