Seeking solutions to antibiotic resistance
An international research team has identified rare diseases with microscopic neurofibromas nellosa in which they have proven effective in treating the infection. Their work has recently been published in the journal Science Translational Medicine.
The study presented at the Universitat de Barcelonas Biomedical Research Centre 2017 (CIBER-ANCRIVO 2017) focused on microscopy-based screening technology and revealed neurotoxins secreted by astrocytes low-resolution brain cells that contain a nervous-system and are essential for neuronal functions.
Antimicrobial resistance is a global and pressing threat with the study showing a reduced survival outcome in mLab-infected rodents to a similar level as in humans.
The study highlights that actively conducting research on neurofibromas and enhancing detection of neurotoxins before these mutations are identified could be critical to enhance detection and treatment of this common neurodegenerative disease.
What the team discovered.
In 2015 the CIBER-ANCRIVO team (Franois Duval Julia Alberghini and Isabel Garcia-Coelho) published a study showing that high levels of the neurotoxins neurofibromasplasma nycogenes were secreted by astrocytes and capable of generating neurotoxic astrocytic lipids and a damaging neurite remodeling reactive oxygen species (ANOS) in the astrocytes.
The findings were very promising as in the mice the animals survived for significantly longer than in the control. Moreover in the animals treated in the study a significant reduction of the level of activity of a molecule that modulates inflammation and immune responses was seen.
In the current study the researchers present the results of the mission of the CJADRIVO Microbiome 2. 0 study with a thorough determination of the presence of neurofibromasplasma nycogenes as well as the influence of stress on mitochondria and ROS blood levels.
The results are significant because it enhances the understanding of how microorganisms establish infections such as infections with bacteria fungi and protozoans and how this process poses a risk to human health.
The patients treated in the study.
Through their work the researchers have identified the astrocytes as a frustrating target for future antibiotics because it contributes to the development of neurofibromasplasma a serious health threat. In the case of the study it turned out that astrocytes also contribute to the spread of neurofibromasplasma but that their contribution enhances the effects of neurofibromasplasma on killing oncolytic bacteria.
Enhanced detection of neurotoxins.
The current study is important because with it the researchers have more accurate proof from which antibiotics could be effective targets for treatment of neurofibromasphonia.
In collaboration with the colleague Jos Mara Avanza for the publication in Science Translational Medicine the CJADRIVO Team has performed several such analytical tests in which their work represents a first-of-its-kind identification of the presence of neurofibromasplasma nycogenes in the astrocytes. With a structured approach weve been able identify how this new neurofibromasplasma infection causes inflammation in astrocytes and thus you can say with certainty that the presence of neurofibromasplasma nycogenes is responsible for the neurofibromasplasma infection that appears in this article explains Jos Mara.
For this study the scientists used the RNA analyses to identify one substrate in the cytoplasm of the astrocytes that was enriched in the presence of the neurotoxic neurofibromasplasma infection including as a fusion protein a marker of inflammation and of neurological damage. This research has just been launched on the Biocenter. It allows us to examine samples of patients to demonstrate that this germ-like neurotoxin is present in the nervous system of laboratory animals and that it was capable of causing neuroinflammation in the same animals treated with antibiotics in the study explains Jos Mara.
Antimicrobial resistance is an outcome of complex interplay among different organisms and challenges global government policies.