Researchers discover process by which amyloid are involved in Alzheimers disease pathology

Gene therapy could one day help to restore memory and stop the progression of Alzheimers disease. A joint-research team has developed a technique whereby amyloid- the most widely studied protein in the brain is actively involved in the progression of Alzheimers disease.

This study which is published in the journal Translational Research reveals a mechanism through which amyloid- promote the accumulation of amyloid- plaques in the brain of mice. The involvement of amyloid- is precisely the opposite to the adaptive immune response to amyloid- mutations that are part of the classical-pathogenic form of the disease.

If you observe any accumulation or clumping of amyloid- plaques in the brains of mice you would have to consult your neurologist because the abnormal area might be due to amyloid- plaques already present in the brain and consequently be responsible for the condition.

Vincentio Violangione a member of the team from the University of Genoa (Milan Italy) and corresponding author of the study.

This study suggests that drugs that are selective for removing very small intruders in the cell nucleus may be an excellent strategy to treat the neurodegenerative disease with minimal toxicity.