Research Suggests Anesthesia During Cues Pollutes the Brains Immune System This Way Future
The idea of anesthetizing patients with anesthetic drugs is a relatively new concept at least in the United States. But researchers at UT Health San Antonio are studying endometrial cancer a tumor that leads to irregular periods menstrual irregularities and menstrual pain. Their study found exposure to anesthetic drugs particularly fentanyl damages cells in the gut that are particularly vulnerable to attack. The human children of this patient population were born prematurely and had a gestation period of just over 49 weeks. Although we live relatively long lives and age ourselves the parameters that determine how many hours we live remain extremely variable.
What were doing with this study is looking at endometrial cancer which we see often says study co-author Dr. Sylvia Tering associate professor of Urology Perioperative and Reproductive medicine at UT Health San Antonio. This study in our particular is focused on investigating whether endometrial cancer can be adequately treated with vaginally administered naloxone yet reducing exposure to fentanyl. Controlling exposure to endometrial cancer is complicated by the sophisticated wiring in the gut that permits the brain to integrate information from multiple senses. In addition doctors administering endometrial cancer invasive procedures are not used to reduce the drug exposure in the participants.
We found endometrial cancer cells with topographic diversity showed destruction in intestinal epithelial pathways which are home to the main gut barrier adds Tering. We also found the chemo-chemical profile which is a very diverse composition of molecules was generated by the endometrial cancer cells in cycles (morphological sex) dependent on the priority of the drug and how it degrades.
It is well established that endometrial cancer responds to antibiotics in a particular manner and we found vaginally administered naloxone degrades endometrial cancer cell survival and capability to replicate adds study co-author Dr. William Jackson a pulmonary medicine expert who practices at Tel Aviv Sourasky Medical Center in Israel and holds the Alberta A. Solomon Distinguished Chair in the field. We believe the deficiency of endometrial cancer response may be secondary to abuse by endometrial cancer patients because of the high need for endometrial cancer surgery in this population.
The paper The effects of the stress of fentanyl on intestinal epithelial cell morphology and function was recently published in the Annals of Internal Medicine.
UT Health San Antonio investigators Kristin Petersen Katharina Mantz Humphrey Nelson Douglas Downey Jennifer Weber Monica Sotomayor William Jackson Andres Nieto Denis Sagare Amaika Tampa and Chrystal Wray professor of obstetrics and gynecology at UT Health San Antonio; and Jennifer Sharma clinical assistant professor of obstetrics at UT Health San Antonio first authors on the study of which 419 patients were followed for an average of 8 months.
The researchers found clear signs of dysregulated gut epithelial expression and decreased levels of genes involved in iron and copper homeostasis particularly in faeces. They also found decreased levels in the gut water of the factor that is involved in thyroid intercalated hormone production and the hormone-resistance pathway which regulates the steroid hormones functioning.