Overestimated Risk of Death in Multiple Myeloma: Patients Who Triedoxidative Management Started After Death
Multiple myeloma is the most common type of lymphoma with about 80 of patients live longer than their cancer initially expected. But the cancer can develop resistance to commonly used radiation treatments so patients start to benefit when theyre considered treatment-selected.
A study published today in the Journal of Bone and Mineral Research reveals that the risk of death in a patient with multiple myeloma who participated in tazarotene (Tav) – an oral adenosine therapy for cases of acute myeloid leukemia (AML) – was even higher than the results expected based on the data.
Tav is a hormone receptor antagonist drug that has been shown to delay disease progression and prolong survival in AML patients with low-dose therapy. The data released today assure us that millions of patients benefit from this life-saving therapy potentially due to a benefit from the selective beta3 integrin inhibitor tazarotene said lead author Ravi Jahangi MD of The University of Texas MD Anderson Cancer Center at Houston (UT Health Houston) an affiliate of The University of Texas MD Anderson that conducted this study. Its unclear but we predict that the benefit from tazarotene may not be for those considered treatment-selected.
The research team analyzed the same data from the Texas Case Western Reserve (TCWR) Multiple Myeloma and verified the high survival rates using Kaplan-Meier analysis. They reported the two-year rate of death due to cancer-causing agents as the incidence among all patients who received cancer treatment and died in 2016. They then scaled the data down to the number of secondary patients who were eligible for this subgroup analysis. Cell was a cancer cell taken from patients who participated in the TAV study who were considered treatment-selected. A Kaplan-Meier analysis was then applied to the data to calculate the absolute risk of death (ANP) achieved by a given treatment strategy from the number of patients in the tav cohort.
The ANP for tav-selected patients (hazard ratio 1. 24) was significantly higher than the ANP for all non-treatment-selected patients (hazard ratio 0. 82). Additionally the ANP for tav-selected patients was significantly higher than the ANP for all other patients (hazard ratio 1. 35). No one would have predicted tav achieved 2-4 years of survival if the benefit rate of live subgroup analysis were overstated said Dr. Jahangi However based on these results we extrapolate the data to value patients based on their therapy plans.
A long-term prospective prospective study with additional patient cohorts is needed to key information warrant.
This study was funded by the National Institutes of Health (R36-BM116879 P30-NS059661 R21-NS094309) and is published in Multiple Myeloma as part of the Wiley Reference Series.
MANDATORY USE OF ORDERS TO THE SUPPORT CLINICAL PRACTICE At the Centers for Disease Control and Depression the National Institute of Neurological Disorders and Stroke (Dialog Micron; DHMR; Bethesda Maryland 20008-20009) collaborated with the National Institute of Allergy and Infectious Diseases the National Institute of Allergy and Infectious Disease and 30 other nongovernmental organizations to develop a product information resource from the treatment of multiple myeloma. Research has shown that patients having command intravenous chemotherapy andor radiation are at advanced stage of their disease having reached statistical significance as compared with their stage intended for chemotherapy induction. More thorough clinical trial is needed. To address this the study recruited the participants of the TrialLIVE cohort comprised of patients who participated in the I. C. R. C. E. TAV study and had been treated at CDC and was considered treatment-selected (i.e. established therapy group) for at least 18 months. This group was followed for the remainder of the 2 years. The investigators also included patients in the TrialLIVE cohort and the current population to determine the clarification of the cancer-causing variables in their data.