New muscle-building compound appears to fight Parkinsons disease by spreading DNA repair
Researchers at Karolinska Institutet in Sweden report an increased survival rate of patients who took an orally-administration of a new muscle-building compound which appears to fight Parkinsons (PD) disease. The results are published in the scientific journal Cell Reports.
PD affects 1. 8 million people in Sweden. Intense muscle burning is thought to contribute to the symptoms of PD yet precisely how this occurs and how the disease develops are unknown.
In patients with PND the muscle cells of the brain that control breathing are progressively damaged causing difficulties with breathing paralysis and deterioration of coordination. This condition is caused by the excessive formation of a protein called Lewy body.
Skin cells with Lewy bodies spread throughout the body.
Previous studies have shown that these skin cells can grow into Lewy bodies which is thought to be an early expansion of the skin cells. Bergmar Schindler researcher at the Department of Clinical Science and Thoracic Medicine and Karolinska Institutet has now tested the effect that oral supplementation with the skin pigmented growth factor Olea Nigula at the dose of 2. 5-4. 6 mg per day in newly diagnosed patients with PND appears to have protective effects against Parkinsons disease.
Following treatment with the skin pigmented growth factor stimulating the plantar skin and then applying continuous pressure on the lower plantar skin with a nail clipper it was found that a significant reduction in the symptoms on the plantar skin was achieved over a period of 17 months. Our results strongly suggest that this compound may also be effective against Parkinsons disease says Bergmar Schindler.
The results can have a dramatic effect on health in women and men. The rich biological activity of the plantar skin and the low toxicity which may make it easier and safer for women and men to maximise their potential makes it especially appealing for men as the compound is well-tolerated Bergmar Schindler explains.
The results could also benefit several other patients with Parkinsons disease. It is well known from previous studies that Parkinsons disease patients in general have a prolonged period of tissue damage of the plantar skin due to the production of Lewy body-Several meta-analyses have shown that the Lewy body in PD do occur in other tissues as well including the trunk and pelvis which gives us reason to suspect that the Lewy body is involved in the development of PD as well.
Olea Nigula is a plantar skin pigment a skin pigment which is active when plants produce a natural spongy substance called sap. Olea pigments are present in many plants and animals especially trees and isopropyls.
Parkinsons disease is a neurodegenerative disorder caused by the loss of dopamine-containing brain cells. This happens when the plantar skin loses the layer of myelin that surrounds nerve cells and which enables them to communicate. Patients affect by Parkinsons disease lose the ability to control their body movements.
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In a study of up to 150 patients Bergmar Schindler and his colleagues have been able to demonstrate that what is beneficial to the skin such as shampoo isnt necessarily beneficial for these patients which in their case was mainly because the patient were able to cultivate a sufficient amount of the plantar skin naturally meaning they were able to restore their ability to walk. In addition the levels of a certain amino acid called L-type amyloid in the Lewy Bodies of PD patients at the time of diagnosis were too high.
Irrespective of these cell types the Oxford-based researchers have found that L-type amyloid organisms increase in the diseased skin cells of patients with PD. This finding could indicate that at least three types of cell or certain combinations of cells may not be sufficient to promote L-type amyloid regeneration and thus the replanting of L-type skin cells.
Such findings were recently published in the scientific journal Nature.