Leptospirosis Subtype Plays a Role Inposed to Higher Risk Among Healthy People Compared to Those with Addictive Behaviors

PHILADELPHIA More than 70 of healthy people with addictions to tobacco and other addictive substances report higher risk of severe leptospirosis. Research has also shown that the severity of patients symptoms is associated with obesity alcohol intake and genetic predisposition to leptospirosis. Importantly this leptospirosis subtypes prevalence can be classified into four distinct subtypes. These subtypes were assessed in a cross-sectional study of more than 1000 adults with no known addictions to tobacco alcohol or other addictive substances (NACIS-TOS) in the Mediterranean region. Results of the study were recently published in the journal Addiction.

As the name implies leptospirosis is a common and frequently recurring skin disorder that accounts for up to 3 trillion in economic and health care costs annually in the United States. The main reasons patients develop leptospirosis include overconsumption of alcoholic beverages (50-100 g (n 153) whereas hundreds of thousands also consume smoked tobacco mostly in infancy. However a specific genetic subtype may also make the skin less susceptible to leptospirosis.

To put it simply this subtype may be of more appeal because despite the common negative impact that tobacco and other addictive substances have on health they may increase the severity of patients symptoms said lead author Jos Angel Castro PhD MPH and director of the Leptospirosis Research Program in the Recimulatory Center of the Mediterranean Diet Optigenetics Clinical Research Unit at the National Centre for Research Excellence in Psychiatry (CARSEP-HON) of the Hospital de la Santa Creu Bella.

Those who have a genetic subtype classified into 4 subtypes may have a two-fold risk of developing leptospirosis. Those who have a genetic subtype grouped into 3 subtypes may have a 2-fold risk of developing leptospirosis. Those who have a genetically and immunosuppressed subtype were predisposed to develop leptospirosis and who were classified into the subtype with higher leptospirosis prevalence and a higher prevalence of severe airway diseases such as asthma and type 1 diabetes had a 2-fold risk of developing leptospirosis and a 1-fold risk of developing asthma COPD or Lymphoma a group of nearly 2000 patients with 80 prevalence of asthma.

These results confirm previous and current meta-analyses showing higher prevalence and higher prevalence of non-Hodgkin lymphoma or lymphoma as well as decreased prevalence of acute myeloid leukaemia in patients with leptospirosis.

We already knew that the prevalence and severity of patients with this subtype was significantly higher than in patients with a genotypically heterogeneous human leukocyte antigen (HLA) combination of exposure to tobacco and alcohol said senior author Ronald Chandler MD MS interpretation psychology doctoral candidate and member of the CARSEP-HON. Nonetheless weve shown that other cancer susceptibility genes and gene expression patterns are also present in the leptospirosis subtype including those related to tobacco uses deleterious effects on immune system hypertension and thyroid hormones.

The study was conducted a year after CEUH using blood specimens collected from 1488 adults with a mean age of 58 both from three and six years. A subset of the study population comprised (n 1016) was included whose DNA was typed into a large set of genes known to regulate immune system function thus grouping the Leptospirosis Subtypes. The DNA was compared with that of an NIH-funded cohort of healthy control participants.

People with a genetic subtype with a combined genetic risk score in the category with the highest combined risk score (Cronbach P . 001) had a two-fold increased risk of developing leptospirosis a two-fold increase in their risk of having asthma and a three-fold increased risk of being diagnosed with a type of bronchitis pneumonia or tough-to-treat cough. Genetic and immunosuppressive subtypes were found in 8. 3 of overall patients resulting in a 2- and a 3-fold increased risk of these diseases.

Alluring as it may be it is an unexpected finding and seems to confirm our previous data. There was the additional surprise of finding one type of allergies which we had linked to tobacco as well as a family history of alcoholism said Dr. Castro.

Dr. Castro