Growing Stem Cell CultureMachine for Multi-Organized Cell Therapy

The main obstacle to the complete eradication of cancer cells in the human body is the so-called cell cycle in most cases. To eradicate a cancer cell it first needs to renew its chromosomes which is known as cell division. Cells that are reshaped to avoid the cell cycle need to be re-seeded with cells that are genetically identical but with extra chromosomes that enable them to divide indefinitely. If the cells there are not able to do this the cycle cannot be cleared. To bypass this stem cell culture machines have been experimenting with cells that share certain features with diseased cells. This is called gene-edited stem cells. Recently one group of researchers from the Polish Academy of Sciences have adopted this way of addressing an issue faced by stem cell culture machines. This group showed that this development can be generalized to expand the number of cancer cells. The stem cell culture did this in a study published in the journal Science Advances.

There is not enough information to keep track of what kind of regenerative medicine treatments the patients are getting. In order to make this information available to doctors and patients who need it we developed an encyclopedia. We also included in the journal article about gene editing technologies in large scale. Then the stem cell culture was able to produce several years worth of reagents (molecular activators) which are needed for implantation and cell therapy. These activator molecules are self-replicating reservoirs of the newly created gene-edited cells. They are also capable of enabling cells in the bloodstream to survive for a long time (in the same way that regular cells do). This reality check was used in the project in collaboration with the research company Fikrichenska Biomedical Research Institute (FIBRE).

Dr. Jacek Witkiewicz Head School of Engineering the Polish Academy of Sciences Innovation and Design Center (KiTECH)