Facial bones can predict early risk of diabetes and obesity

Bones with rising levels of osmolality-concentration of gases formed in the body when cells break down sugar -can predict a predisposition to type 2 diabetes and obesity a new study has found.

Osmolality-a chemical building block of protein and carbohydrates in cells-increases the likelihood for metabolic diseases such as diabetes and obesity. Luxurious aurea which contains a large number of sugar molecules in both blood and urine is essential for normal function.

Metabolic diseases are a worldwide health threat and the only colorless genetic defect is inpatients of a rare Icelandic population (1000-year-olds). This has led international researchers to examine associations between osmolality-which is found most often in bone and teeth -and insulin resistance in humans.

Dr. Ramakrishna Das from the University of Adelaides Birmingham Medical School led the research which has recently been published in the international journal Gut.

We do not yet understand the potential function of osmolality but we suspect it plays a central role in regulating insulin resistance. This research may help to develop methods to identify individuals who carry familial risk preventing them from developing type 2 diabetes and obesity he said.

Vendingry for the database.

Jeremy Copsey Professor of Anesthesiology Anaesthesia Neuroscience and Critical Care at the University of Nebraska Medical Center (UNMC Omaha) and principal investigator on the project said there is an urgent need for the discovery of novel diagnostics for the management of patients with diabetes and obesity.

This research could also assist in the identification of diagnostic and prognostic markers in order to inform therapeutic approaches that reduce unexplained weight loss and provide patients with records to tell us how their disease would have progressed Professor Copsey said.

The subjects for this study who were either obese or overweight-matched those of European and African American ancestry whose lifestyle the subjects had completed self-assessed lifestyle diaries throughout the 1980s and 90s. The patients explained their lifestyle diaries and body mass index (BMI) scores including service markers such as blood sugar cholesterol levels and blood lipids previously conducted biopsies of their teeth.

We were surprised that BMI score changes of more than 1 kgm2 over the past decade were associated with increased risk for type 2 diabetes and in particular that higher BMI still was associated with increased insulin resistance. Im particularly proud of the collaboration amongst worlds leading epidemiology and obesity researchers Professor Copsey said.

We believe that a comparable or greater degree of accuracy could be achieved and with increasing experience we may one day have created new diagnostic markers and may be able to have an accurate translation for average Americans Africans Europeans Asians and South Americans he added.

The results from this cohort are in line with previous studies which suggest that infants exposed to toxic chemicals in utero have shorter odds of developing diabetes and obesity.

High BMI is a known predictor for cardiovascular diseases long term cognitive disorders and psychiatric disorders.