Chronic stress can lead to neuronal loss of control over gene expression. A group of scientists led by Claus C. Lambesis, PhD, of West Germany’s Biozentrum, and at the University of Freiburg (Germany), have shown that both cell signaling pathways and complement pathways determine cell fate when stressed. The findings were published on May 15 in eLife.
Cell signaling appears to play an important role in physical equilibrium in the body. Cell division can be stopped, even substantially, by activating signaling in the nucleus. This happens partially or completely by means of induced pluripotent stem cells (iPSCs) – in which all genetic information of the donor recipient cell is transformed into a second line of cells, which thus nourish the recipient. SPCs are thus a promising source of cells for future regenerative therapies for specific organs such as bone, cartilage, heart, and kidneys. Unfortunately, in the course of biological activity they also tend to generate specialized immune cells. In particular, their stem function is important to the propagation of pluripotent stem cells. And abnormalities of their proliferation can also be associated with numerous diseases associated with cell stress and stem function.